99久久人妻精品免费二区,色卡网站PROC免费,亚洲小说区图片区色综合网,在免费JIZZJIZZ在线播放

您好,歡迎進(jìn)入上海力敏實(shí)業(yè)有限公司網(wǎng)站!
一鍵分享網(wǎng)站到:
您現(xiàn)在的位置:首頁(yè) >> 產(chǎn)品中心 >> 生化試劑、抗體、血清 >> 細(xì)胞因子 >> RD 416-ml-010M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

  • 更新時(shí)間:  2023-07-24
  • 產(chǎn)品型號(hào):  RD 416-ml-010
  • 簡(jiǎn)單描述
  • M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF也被稱(chēng)為CSF1細(xì)胞因子,巨噬細(xì)胞的存活,增殖和分化(1)主要監(jiān)管機(jī)構(gòu)纖細(xì)說(shuō)明書(shū)在產(chǎn)品詳細(xì)介紹中
詳細(xì)介紹

M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

DESCRIPTION
Source E. coliderived
Lys33Glu262,
with an Nterminal
Met
Accession # Q3U4F9
Nterminal
Sequence
Analysis
Met
Structure / Form Disulfidelinked
homodimer
Predicted Molecular
Mass
26 kDa (monomer)
SPECIFICATIONS
SDSPAGE
29 kDa, reducing conditions
Activity Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia lymphoblast cells. Halenbeck, R. et al. (1989)
Biotechnology 7:710.
The ED50 for this effect is typically 0.5-3 ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >97%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. See Certificate of Analysis for details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediay at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
MCSF,
also known as CSF1,
is a fourαhelicalbundle
cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1 3).
MCSF
is also essential for the survival and proliferation of osteoclast progenitors (1, 4). MCSF
also primes and enhances macrophage killing of tumor cells and
microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). MCSF
increases during
pregnancy to support implantation and growth of the decidua and placenta (5). Sources of MCSF
include fibroblasts, activated macrophages, endometrial secretory
epithelium, bone marrow stromal cells and activated endothelial cells (1 5).
The MCSF
receptor (cfms)
transduces its pleotropic effects and mediates its
endocytosis. MCSF
mRNAs of various sizes occur (3 9).
Full length mouse MCSF
transcripts encode a 520 amino acid (aa) type I transmembrane (TM) protein with
a 462 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two
proteolytically cleaved, secreted dimers. One is an Nand
Oglycosylated
86 kDa dimer, while the other is modified by both glycosylation and chondroitinsulfate
proteoglycan (PG) to generate a 200 kDa subunit. Although PGmodified
MCSF
can circulate, it may be immobilized by attachment to type V collagen (8). Shorter
transcripts encode M CSF
that lacks cleavage and PG sites and produces an Nglycosylated
68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7).
Although forms may vary in activity and halflife,
all contain the Nterminal
150 aa portion that is necessary and sufficient for interaction with the M CSF
receptor
(10, 11). The first 229 aa of mature mouse MCSF
shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human MCSF,
respectively (12, 13). Human MCSF
is active in the mouse, but mouse MCSF
is reported to be speciesspecific.
M-CSF的重組小鼠細(xì)胞因子Recombinant Mouse M-CSF

References:
1. Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.
2. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.
3. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.
4. Ryan, G.R. et al. (2001) Blood 98:74.
5. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.
6. Nandi, S. et al. (2006) Blood 107:786.
7. Rettenmier, C.W. and M.F. Roussel (1988) Mol. Cell Biol. 8:5026.
8. Suzu, S. et al. (1992) J. Biol. Chem. 267:16812.
9. Manos, M.M. (1988) Mol. Cell. Biol. 8:5035.
10. Koths, K. (1997) Mol. Reprod. Dev. 46:31.
11. Jang, MH.
et al. (2006) J. Immunol. 177:4055.
12. DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.
13. Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.

 

上海力敏實(shí)業(yè)有限公司代理R&D產(chǎn)品,咨詢(xún) 詳細(xì)產(chǎn)品信息


留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話(huà):

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說(shuō)明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫(xiě)阿拉伯?dāng)?shù)字),如:三加四=7
被黑人姿势猛到抽搐视频| 嗯啊H客厅HH粗汉H涨奶| 精品人妻AV一区二区三区| 中文字幕一区二区三区日韩精品| 日韩AV在线观看| 白嫩少妇激情无码| 国产香蕉九九久久精品免费| 中文字幕无码乱人伦| 日韩av无码免费播放| 少妇无码AV无码专区在线观看| 动漫人物桶动漫人物免费观看网站 | 意大利性经典XXXXX| 狠狠躁日日躁夜夜躁A片| 野花日本免费完整版高清版直播| 嗯啊H客厅HH粗汉H涨奶| 人妻精品久久久久中文字幕| 公交车一个接着一个C| 性强烈的老熟女偷小伙| 亚洲精品婷婷无码成人A片在线| 欧美人与ZOZOZOXXXX| 亚洲精品AV无码喷奶水网站| 麻豆乱码国产一区二区三区| 老熟女强人国产在线播放| 真实刺激交换娇妻13篇| 米奇7777狠狠狠狠视频影院| 亚洲AV永久无码精品一百度影院| 日日AV夜夜添久久奶无码 | 双性玩弄调教NP产乳孕交灌尿 | 99久久99久久精品国产片| 天天躁日日躁狠狠躁日日躁黑人 | 日韩精品无码一本二本三本| 国产精品久久人妻拍拍水牛影视 | 强行扒开双腿猛烈进入免费版| 成人视频网站| 黑人刚破完处就三P| 狠狠躁夜夜躁人人爽蜜桃| 无码人妻丰满熟妇啪啪网站牛牛| 国产超碰人人爽人人做人人添 | HD女人奶水授乳MILK| 少妇无码太爽了不卡视频在线看| 疯狂的交换小雅小姿1~6|